HYAL Question Bank

Section 1: Hyaluronidase Basics

What is the primary function of Hyaluronidase?

a) Synthesizes Hyaluronic Acid
b) Degrades Hyaluronic Acid
c) Produces collagen
d) Repairs damaged skin

Section 1: Hyaluronidase Basics

Hyaluronidase is most commonly found in which of the following?

a) Venoms
b) Bacteria
c) Fungi
d) Plants

Section 1: Hyaluronidase Basics

What type of Hyaluronidase is specific to the testes?

a) HYAL-1
b) HYAL-2
c) HYAL-3
d) PH-20

Section 1: Hyaluronidase Basics

Recombinant human Hyaluronidase is known to be how much purer than bovine preparations?

a) 10 times purer
b) 50 times purer
c) 100 times purer
d) 150 times purer

Section 1: Hyaluronidase Basics

Which pH range activates acid-active Hyaluronidases?

a) 1-2
b) 3-4
c) 5-6
d) 7-8

Section 2: Hyaluronidase Mechanism and Body Interaction

What is the half-life of Hyaluronidase in the body?

a) 30 seconds
b) 2 minutes
c) 5 minutes
d) 10 minutes

Section 2: Hyaluronidase Mechanism and Body Interaction

Hyaluronidase increases tissue permeability by:

a) Strengthening the ECM
b) Reducing the viscosity of the ECM
c) Enhancing collagen production
d) Promoting cell division

Section 2: Hyaluronidase Mechanism and Body Interaction

Which type of bond does Hyaluronidase break in Hyaluronic Acid?

a) Peptide bond
b) Glycosidic bond
c) Hydrogen bond
d) Ionic bond

Section 2: Hyaluronidase Mechanism and Body Interaction

What is the primary factor that affects Hyaluronidase stability?

a) Temperature
b) Enzyme concentration
c) pH levels
d) Sunlight exposure

Section 2: Hyaluronidase Mechanism and Body Interaction

Where is Hyaluronidase primarily metabolized in the body?

a) Skin
b) Kidneys and liver
c) Lungs
d) Bloodstream

Section 3: Hyaluronidase Clinical Applications

Hyaluronidase is commonly used in aesthetic practices to:

a) Increase HA filler duration
b) Break down unacceptable HA fillers
c) Enhance skin pigmentation
d) Stimulate hair growth

Section 3: Hyaluronidase Clinical Applications

What is the recommended storage temperature for Hyaluronidase?

a) -10°C to 0°C
b) 2°C to 8°C
c) 15°C to 25°C
d) 30°C to 40°C

Section 3: Hyaluronidase Clinical Applications

Which of the following is a serious potential complication of Hyaluronidase use?

a) Nausea
b) Skin dryness
c) Anaphylaxis
d) Mild itching

Section 3: Hyaluronidase Clinical Applications

What is a common side effect of Hyaluronidase injections?

a) Permanent scarring
b) Bruising and swelling
c) Hyperpigmentation
d) Loss of hair

Section 3: Hyaluronidase Clinical Applications

Hyaluronidase can be used to treat which of the following conditions?

a) Eczema
b) Vascular occlusion
c) Psoriasis
d) Alopecia

Section 4: Hyaluronidase in Procedures

What is the typical needle size used for Hyaluronidase injections?

a) 18G
b) 22G
c) 27G
d) 30G

Section 4: Hyaluronidase in Procedures

Which technique is recommended for optimal Hyaluronidase injection results?

a) Deep intramuscular injection
b) Subcutaneous injection
c) Intravenous injection
d) Superficial dermal injection

Section 4: Hyaluronidase in Procedures

Which area should be avoided for Hyaluronidase treatment?

a) Recently botulinum-treated areas
b) Forearm
c) Nasolabial fold
d) Upper eyelid

Section 4: Hyaluronidase in Procedures

What is the typical dosage range for Hyaluronidase when correcting HA fillers?

a) 1-2 units
b) 4-8 units
c) 10-15 units
d) 20-25 units

Section 4: Hyaluronidase in Procedures

Hyaluronidase should be used with caution when combined with which type of medications?

a) Antibiotics
b) Antihistamines
c) NSAIDs
d) Antivirals

Section 5: Advanced Applications of Hyaluronidase

What is the effect of Mannitol when included in Hyaluronidase formulations?

a) Reduces enzyme activity
b) Enhances product penetration
c) Increases viscosity
d) Promotes enzyme degradation

Section 5: Advanced Applications of Hyaluronidase

How does Hyaluronidase affect scar tissue?

a) Increases rigidity
b) Softens and reduces the density
c) Causes more scar formation
d) Does not affect scar tissue

Section 5: Advanced Applications of Hyaluronidase

Which aesthetic complication is Hyaluronidase NOT used to treat?

a) Granulomas
b) Vascular occlusion
c) Excessive hair growth
d) Overfilling of HA fillers

Section 5: Advanced Applications of Hyaluronidase

Hyaluronidase is often combined with which device for enhanced skin penetration?

a) Laser
b) Dermapen
c) Cryotherapy
d) Ultrasound

Section 5: Advanced Applications of Hyaluronidase

Which skin type condition is contraindicated for Hyaluronidase use?

a) Oily skin
b) Active skin infections
c) Dry skin
d) Combination skin

Section 6: Hyaluronidase Clinical Studies

What was the primary finding of the clinical trial involving small unit doses of Hyaluronidase?

a) It caused more filler to be produced
b) It removed entire implants
c) It allowed removal of minute quantities of filler without removing the entire implant
d) It was ineffective in all cases

Section 6: Hyaluronidase Clinical Studies

In a retrospective study, how many patients were assessed for Hyaluronidase’s effectiveness in correcting filler complications?

a) 10 patients
b) 25 patients
c) 50 patients
d) 100 patients

Section 6: Hyaluronidase Clinical Studies

What percentage of patients experience complications with HA filler that require Hyaluronidase?

a) 0.05% to 0.69%
b) 1% to 5%
c) 10% to 20%
d) 25% to 30%

Section 6: Hyaluronidase Clinical Studies

What is the recommended interval between Hyaluronidase treatment sessions?

a) 1 day
b) 2 days
c) 7 days
d) 15 days

Section 6: Hyaluronidase Clinical Studies

Which factor does NOT affect the dosage of Hyaluronidase?

a) Type of hyaluronic acid filler
b) Concentration of Hyaluronic Acid
c) Patient’s age
d) Amount of cross-linking in the filler